D-CYCLOSERINE AUGMENTATION IN BEHAVIORAL THERAPY FOR OBSESSIVE-COMPULSIVE DISORDER: A META-ANALYSIS



Pathophysiology of Myelodysplastic Syndromes

Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes.Its pathophysiology relies on a diversity of mechanisms supported by genetic events that develop in aging hematopoietic stem cells.Deletion and mutations trigger epigenetic modifications, and co-transcriptional and post-transcriptional deregulations of gene exp

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Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Mutation in TP53 is a common genetic alteration in human cancers.Certain tumor associated sterilite 70 quart p53 missense mutants acquire gain-of-function (GOF) properties and confer oncogenic phenotypes including enhanced chemoresistance.The colorectal cancers (CRC) harboring mutant p53 are generally aggressive in nature and difficult to treat.To

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